| Item Type | Name |
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Concept
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Models, Chemical
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Concept
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Models, Molecular
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Concept
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Mice, Transgenic
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Concept
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Models, Genetic
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Concept
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Mice, Inbred BALB C
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Concept
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Mice, Inbred C57BL
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Concept
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Mice, Nude
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Concept
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Linear Models
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Concept
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Mice, Knockout
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Concept
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Genetic Association Studies
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Concept
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Mice
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Concept
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Models, Statistical
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Concept
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Disease Models, Animal
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Concept
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Models, Biological
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Concept
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Prospective Studies
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Concept
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Mice, SCID
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Concept
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Mice, Inbred NOD
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Academic Article
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Intramolecular amide bonds stabilize pili on the surface of bacilli.
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Academic Article
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Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine.
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Academic Article
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A selective fluorescent probe for carbon monoxide imaging in living cells.
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Academic Article
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Structural and biochemical characterization of N5-carboxyaminoimidazole ribonucleotide synthetase and N5-carboxyaminoimidazole ribonucleotide mutase from Staphylococcus aureus.
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Academic Article
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The oxidation-sensing regulator (MosR) is a new redox-dependent transcription factor in Mycobacterium tuberculosis.
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Academic Article
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Golden pigment production and virulence gene expression are affected by metabolisms in Staphylococcus aureus.
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Academic Article
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A new oxidative sensing and regulation pathway mediated by the MgrA homologue SarZ in Staphylococcus aureus.
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Academic Article
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Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.
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Academic Article
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Binding of ReO4(-) with an engineered MoO4(2-)-binding protein: towards a new approach in radiopharmaceutical applications.
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Academic Article
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An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus.
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Academic Article
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Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA.
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Academic Article
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FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA.
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Academic Article
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HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis.
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Academic Article
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Blood-brain barrier permeable gold nanoparticles: an efficient delivery platform for enhanced malignant glioma therapy and imaging.
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Academic Article
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A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
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Academic Article
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Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming.
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Academic Article
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ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.
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Academic Article
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Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.
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Academic Article
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The Pseudomonas aeruginosa multidrug efflux regulator MexR uses an oxidation-sensing mechanism.
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Academic Article
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Preparation of DNA containing 5-hydroxymethyl-2'-deoxycytidine modification through phosphoramidites with TBDMS as 5-hydroxymethyl protecting group.
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Academic Article
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Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing.
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Academic Article
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Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase.
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Academic Article
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Proteome-wide quantification and characterization of oxidation-sensitive cysteines in pathogenic bacteria.
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Academic Article
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Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO.
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Academic Article
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A diazirine-based nucleoside analogue for efficient DNA interstrand photocross-linking.
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Academic Article
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Dynamic RNA modifications in posttranscriptional regulation.
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Academic Article
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Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA.
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Academic Article
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Detection of mismatched 5-hydroxymethyluracil in DNA by selective chemical labeling.
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Academic Article
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Aureusimines in Staphylococcus aureus are not involved in virulence.
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Academic Article
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Using the bias from flow to elucidate single DNA repair protein sliding and interactions with DNA.
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Academic Article
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High-resolution N(6) -methyladenosine (m(6) A) map using photo-crosslinking-assisted m(6) A sequencing.
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Academic Article
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Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics.
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Academic Article
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Silver-catalyzed intermolecular amination of C--H groups.
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Academic Article
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Chemical methods to study protein-nucleic acid interactions.
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Academic Article
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Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA.
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Academic Article
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Crystal structures of SlyA protein, a master virulence regulator of Salmonella, in free and DNA-bound states.
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Academic Article
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Oxidative dealkylation DNA repair mediated by the mononuclear non-heme iron AlkB proteins.
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Academic Article
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Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance.
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Academic Article
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Bioorthogonal labeling of 5-hydroxymethylcytosine in genomic DNA and diazirine-based DNA photo-cross-linking probes.
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Academic Article
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Detection of 5-hydroxymethylcytosine in DNA by transferring a keto-glucose by using T4 phage ß-glucosyltransferase.
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Academic Article
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Reversible RNA adenosine methylation in biological regulation.
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Academic Article
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Crystal structure of the RNA demethylase ALKBH5 from zebrafish.
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Academic Article
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Pseudomonas aeruginosa OspR is an oxidative stress sensing regulator that affects pigment production, antibiotic resistance and dissemination during infection.
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Academic Article
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Molecular mechanism and structure of the Saccharomyces cerevisiae iron regulator Aft2.
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Academic Article
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In the Staphylococcus aureus two-component system sae, the response regulator SaeR binds to a direct repeat sequence and DNA binding requires phosphorylation by the sensor kinase SaeS.
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Academic Article
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Interaction of human and bacterial AlkB proteins with DNA as probed through chemical cross-linking studies.
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Academic Article
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Synthesis of a FTO inhibitor with anticonvulsant activity.
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Academic Article
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Targeting MgrA-mediated virulence regulation in Staphylococcus aureus.
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Academic Article
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Tet-assisted bisulfite sequencing of 5-hydroxymethylcytosine.
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Academic Article
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Modeling non-heme iron proteins.
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Academic Article
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Structure determination of DNA methylation lesions N1-meA and N3-meC in duplex DNA using a cross-linked protein-DNA system.
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Academic Article
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Gold(I)-catalyzed formation of 3-pyrazolines through cycloaddition of diaziridine to alkynes.
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Academic Article
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Detection of 5-hydroxymethylcytosine in a combined glycosylation restriction analysis (CGRA) using restriction enzyme Taq(a)I.
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Academic Article
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A protein engineered to bind uranyl selectively and with femtomolar affinity.
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Academic Article
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Engineering bacterial two-component system PmrA/PmrB to sense lanthanide ions.
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Academic Article
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Live Cell MicroRNA Imaging Using Cascade Hybridization Reaction.
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Academic Article
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High-Resolution Mapping of N6-Methyladenosine in Transcriptome and Genome Using a Photo-Crosslinking-Assisted Strategy.
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Academic Article
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Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation.
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Academic Article
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Base-resolution detection of N4-methylcytosine in genomic DNA using 4mC-Tet-assisted-bisulfite- sequencing.
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Academic Article
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The dynamic N(1)-methyladenosine methylome in eukaryotic messenger RNA.
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Academic Article
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Identification of MLL-fusion/MYC?miR-26?TET1 signaling circuit in MLL-rearranged leukemia.
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Academic Article
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A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations.
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Academic Article
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YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA.
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Academic Article
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Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning.
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Academic Article
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RNA modifications modulate gene expression during development.
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Academic Article
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m6A facilitates hippocampus-dependent learning and memory through YTHDF1.
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Academic Article
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FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function.
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Academic Article
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Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis.
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Academic Article
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Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm.
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Academic Article
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m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.
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Academic Article
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Phasing Gene Expression: mRNA N6-Methyladenosine Regulates Temporal Progression of Mammalian Cortical Neurogenesis.
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Academic Article
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Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation.
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Academic Article
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Kinetic gating mechanism of DNA damage recognition by Rad4/XPC.
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Academic Article
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High-Resolution Mapping of N 6-Methyladenosine Using m6A Crosslinking Immunoprecipitation Sequencing (m6A-CLIP-Seq).
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Academic Article
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Transcriptome-wide reprogramming of N6-methyladenosine modification by the mouse microbiome.
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Grant
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Mechanisms of Pancreatic Cancer Inhibition by SPARC
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Grant
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Mechanism of SPARC peptide FSEC inhibition of angiogenesis in neuroblastoma
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Academic Article
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Inhibition of Copper Transport Induces Apoptosis in Triple-Negative Breast Cancer Cells and Suppresses Tumor Angiogenesis.
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Academic Article
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Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA.
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Academic Article
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METTL14 is essential for ß-cell survival and insulin secretion.
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Academic Article
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m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
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Academic Article
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FMRP Modulates Neural Differentiation through m6A-Dependent mRNA Nuclear Export.
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Academic Article
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Detailed modeling of positive selection improves detection of cancer driver genes.
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Academic Article
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Prognostic implications of 5-hydroxymethylcytosines from circulating cell-free DNA in diffuse large B-cell lymphoma.
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Academic Article
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The RNA-binding protein FMRP facilitates the nuclear export of N6-methyladenosine-containing mRNAs.
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Academic Article
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RADAR: differential analysis of MeRIP-seq data with a random effect model.
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Academic Article
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m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination.
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Academic Article
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N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription.
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Academic Article
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Keth-seq for transcriptome-wide RNA structure mapping.
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Academic Article
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DNA 5-Methylcytosine-Specific Amplification and Sequencing.
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Academic Article
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N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA.
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Academic Article
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Kethoxal-assisted single-stranded DNA sequencing captures global transcription dynamics and enhancer activity in situ.
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Academic Article
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REPIC: a database for exploring the N6-methyladenosine methylome.
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Academic Article
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Control of Early B Cell Development by the RNA N6-Methyladenosine Methylation.
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Academic Article
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A New Model of Spontaneous Colitis in Mice Induced by Deletion of an RNA m6A Methyltransferase Component METTL14 in T Cells.
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Academic Article
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Direct DNA crosslinking with CAP-C uncovers transcription-dependent chromatin organization at high resolution.
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Academic Article
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Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation.
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Academic Article
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N6-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation.
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Academic Article
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N6 -methyladenosine modification of lncRNA Pvt1 governs epidermal stemness.
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Academic Article
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Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.
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Academic Article
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Wnt signaling pathway involvement in genotypic and phenotypic variations in Waardenburg syndrome type 2 with MITF mutations.
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Academic Article
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METTL14 facilitates global genome repair and suppresses skin tumorigenesis.
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Academic Article
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HRD1-mediated METTL14 degradation regulates m6A mRNA modification to suppress ER proteotoxic liver disease.
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Academic Article
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The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation.
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Academic Article
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FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development.
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Academic Article
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Quantitative sequencing using BID-seq uncovers abundant pseudouridines in mammalian mRNA at base resolution.
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Academic Article
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spKAS-seq reveals R-loop dynamics using low-input materials by detecting single-stranded DNA with strand specificity.
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Academic Article
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Detection of m6A RNA modifications at single-nucleotide resolution using m6A-selective allyl chemical labeling and sequencing.
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Academic Article
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N6-adenomethylation of GsdmC is essential for Lgr5+ stem cell survival to maintain normal colonic epithelial morphogenesis.
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Academic Article
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Transcriptome-wide profiling and quantification of N6-methyladenosine by enzyme-assisted adenosine deamination.
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Concept
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Mouse Embryonic Stem Cells
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Grant
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RNA methylation and regulatory T cells
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Grant
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Interrogation of dynamic RNA modifications in beta cells in type 1 diabetes
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Grant
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Recognition and mechanism of N6-methyl adenosine modifications
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Grant
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Global Cysteine Modifications in Human Pathogens
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Grant
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Direct Oxidative Nucleic Acids Demethylation
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Grant
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Base-resolution sequencing of m6A in RNA
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Grant
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Direct Oxidative Nucleic Acids Demethylation
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Academic Article
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METTL14 is a chromatin regulator independent of its RNA N6-methyladenosine methyltransferase activity.
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Academic Article
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YTHDF2/m6 A/NF-?B axis controls anti-tumor immunity by regulating intratumoral Tregs.
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Academic Article
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YTHDF2 inhibition potentiates radiotherapy antitumor efficacy.
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Academic Article
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BID-seq for transcriptome-wide quantitative sequencing of mRNA pseudouridine at base resolution.
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Academic Article
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Sequencing of N6-methyl-deoxyadenosine at single-base resolution across the mammalian genome.
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